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Ampreloxetine hydrochloride
CAS No. 1227056-87-2
Ampreloxetine hydrochloride( —— )
Catalog No. M36095 CAS No. 1227056-87-2
Ampreloxetine hydrochloride (TD-9855 HCl) has anti-inflammatory activity and is a potential compound for the treatment of depression and Alzheimer's disease.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 122 | Get Quote |
|
| 5MG | 187 | Get Quote |
|
| 10MG | 306 | Get Quote |
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| 25MG | 503 | Get Quote |
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| 50MG | 725 | Get Quote |
|
| 100MG | 972 | Get Quote |
|
| 500MG | 1962 | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameAmpreloxetine hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionAmpreloxetine hydrochloride (TD-9855 HCl) has anti-inflammatory activity and is a potential compound for the treatment of depression and Alzheimer's disease.
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DescriptionAmpreloxetine (TD-9855) hydrochloride is an orally active and CNS-penetrant inhibitor of Norepinephrine transporter (NET) and Serotonin 5-HT uptake transporter (SERT), but not Dopamine transporter (DAT). Ampreloxetine hydrochloride binds norepinephrine transporters (NET) and serotonin transporters (SERT) with EC50 values of 11.7 ng/mL and 50.8 ng/mL, respectively, in plasma.
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In Vitro——
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In VivoAnimal Model:RatDosage:0.3, 1, 5, 10, 30, and 60mg/kg Administration:PO; euthanized by decapitation at 0.5, 2, 4, 6, and 8 hr for 5mg/ kg dose level; 2 hr for 0.3, 1, 10, 30, and 60mg/kg dose levels Result:In the effect compartment PK/PD analysis for NET and SERT occupancy, the estimated EC50 for occupancy was 11.7ng/mL for NET and 50.8ng/mL for SERT in rat spinal cords, and the projected human plasma EC50 values were 5.5ng/mL for NET and 23.9ng/mL for SERT.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number1227056-87-2
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Formula Weight357.8
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Molecular FormulaC18H19ClF3NO
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (279.49 mM; Ultrasonic )
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SMILESCl.FC=1C=C(F)C(OCC=2C=CC=CC2C3CCNCC3)=C(F)C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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JMJD6 inhibitor WL12
2H-1-Benzopyran-2-one, 3-(3H-imidazo[4,5-c]pyridin-2-yl)-6-methyl- is a first-in-class JMJD6 inhibitor and was shown to be able to suppress JMJD6-dependent cancer cell proliferation including cervical and liver cancer cells.
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[Ala1,?3,?11,?15]?-?...
[Ala1,3,11,15]-Endothelin (TFA) is a highly selective for endothelin A (ETA) and endothelin B (ETB) receptor.[Ala1,?3,?11,?15]?-?Endothelin is a selective ETB endothelin receptor agonist (IC50 values are 0.33 and 2200 nM for displacing [125I]-ET-1 from ETB and ETA receptors respectively).
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Oxyphyllacinol
Oxyphyllacinol has antidiarrheal activity.Oxyphyllacinol has been shown to treat dementia. Oxyphyllacinol was isolated from the S. nodiflora water fraction, while the S. nodiflora water fraction has been shown to have antioxidant and anti-aging activities, inducing mitochondrial activity and increasing ctt1 gene expression by regulating stress tolerance response.
